MONOTONE SMOOTHING WITH APPLICATION TO DOSE-RESPONSE CURVES AND THE ASSESSMENT OF SYNERGISM

被引：138

作者：

KELLY, C

RICE, J

机构：

来源：

BIOMETRICS | 1990年 / 46卷 / 04期

关键词：

DOSE-RESPONSE CURVES; MONOTONE SMOOTHING; SPLINE; SYNERGY;

D O I：

10.2307/2532449

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A spline-based procedure for monotone curve smoothing is proposed and is illustrated by application to dose-response curves. It is then shown how such smoothing can be applied to assess possible synergism or antagonism of two drugs.

引用

页码：1071 / 1085

页数：15

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