EFFECT OF LY-83583 ON RELAXATION INDUCED BY NONADRENERGIC NONCHOLINERGIC NERVE-STIMULATION AND EXOGENOUS NITRIC-OXIDE IN THE RAT GASTRIC FUNDUS

被引：65

作者：

BARBIER, AJM ^{[1
]}

LEFEBVRE, RA ^{[1
]}

机构：

[1] STATE UNIV GHENT,SCH MED,HEYMANS INST PHARMACOL,DE PINTELAAN 185,B-9000 GENT,BELGIUM

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 219卷 / 02期

关键词：

GASTRIC FUNDUS (RAT); NONADRENERGIC NONCHOLINERGIC (NANC); NITRIC OXIDE (NO); LY-83583;

D O I：

10.1016/0014-2999(92)90315-U

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the rat gastric fundus, the reported cGMP-lowering agent LY 83583 (10(-5) M) inhibited the relaxation induced by nitric oxide (NO), without altering the response to isoprenaline, vasoactive intestinal polypeptide, sodium nitroprusside or electrical field stimulation of inhibitory non-adrenergic non-cholinergic neurones, which are thought to release NO. Incubation with superoxide dismutase partially prevented the effect of LY 83583. When added during a relaxation maintained by continuous NO infusion, LY 83583 reversed the relaxation. It is concluded that LY 83583 inactivates exogenous NO through the generation of superoxide anions.

引用

页码：331 / 334

页数：4

共 10 条

[1] BOECKXTAENS GE, 1991, THESIS UIA ANTWERP
[2] FURCHGOTT RF, 1991, BLOOD VESSELS, V28, P52
[3] DIFFERENTIATION BY HYDROQUINONE OF RELAXATIONS INDUCED BY EXOGENOUS AND ENDOGENOUS NITRATES IN NONVASCULAR SMOOTH-MUSCLE - ROLE OF SUPEROXIDE ANIONS
HOBBS, AJ
TUCKER, JF
GIBSON, A
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1991, 104 (03) : 645 - 650
[4] CONTROL OF CORONARY VASCULAR TONE BY NITRIC-OXIDE
KELM, M
SCHRADER, J
[J]. CIRCULATION RESEARCH, 1990, 66 (06) : 1561 - 1575
[5] LI CG, 1990, EUR J PHARMACOL, V191, P303
[6] MALTA E, 1988, N-S ARCH PHARMACOL, V337, P459
[7] MCCALL T, 1962, TRENDS PHARMACOL SCI, V13, P1
[8] MULSCH A, 1988, J PHARMACOL EXP THER, V247, P283
[9] SCHMIDT MJ, 1985, J PHARMACOL EXP THER, V232, P764
[10] SHENG H, 1991, British Journal of Pharmacology, V104, p137P

← 1 →