STUDIES ON THE MECHANISM OF ACTION OF (5R)-(Z)-6-(1-METHYL-1,2,3-TRIAZOL-4-YLMETHYLENE)PENEM-3-CARBOXYLIC ACID (BRL-42715), A POTENT INHIBITOR OF BACTERIAL BETA-LACTAMASE

被引:25
作者
BROOM, NJP [1 ]
FARMER, TH [1 ]
OSBORNE, NF [1 ]
TYLER, JW [1 ]
机构
[1] SMITHKLINE BEECHAM,BROCKHAM PK,BETCHWORTH RH3 7AJ,SURREY,ENGLAND
关键词
D O I
10.1039/c39920001663
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A novel base catalysed rearrangement of (5R)-(Z)-6-(1-methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid (BRL 42715) is reported together with its implications concerning the mechanism of inactivation of beta-lactamases by this compound.
引用
收藏
页码:1663 / 1664
页数:2
相关论文
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