STUDIES ON THE MECHANISM OF ACTION OF (5R)-(Z)-6-(1-METHYL-1,2,3-TRIAZOL-4-YLMETHYLENE)PENEM-3-CARBOXYLIC ACID (BRL-42715), A POTENT INHIBITOR OF BACTERIAL BETA-LACTAMASE
A novel base catalysed rearrangement of (5R)-(Z)-6-(1-methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid (BRL 42715) is reported together with its implications concerning the mechanism of inactivation of beta-lactamases by this compound.