LINCOSAMIDE ANTIBIOTICS STIMULATE DISSOCIATION OF PEPTIDYL-TRANSFER RNA FROM RIBOSOMES

被引：26

作者：

MENNINGER, JR

COLEMAN, RA

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 09期

关键词：

D O I：

10.1128/AAC.37.9.2027

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

At nonpermissive temperatures the peptidyl-tRNA hydrolase of pth(Ts) bacterial mutants is inactivated, and cells accumulate peptidyl-tRNA and die. Doses of erythromycin, lincomycin, or clindamycin that inhibited the growth of antibiotic-hypersensitive DB-11 pth+ cells accelerated the killing of DB-11 pth(Ts) cells at nonpermissive temperatures. Erythromycin and lincomycin also stimulated the accumulation of peptidyl-tRNA. Lincomycin and clindamycin stimulated peptidyl-tRNA dissociation from ribosomes.

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页码：2027 / 2029

页数：3

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