PROOXIDANT ROLE OF VITAMIN-E IN COPPER-INDUCED LIPID-PEROXIDATION

被引：78

作者：

MAIORINO, M ^{[1
]}

ZAMBURLINI, A ^{[1
]}

ROVERI, A ^{[1
]}

URSINI, F ^{[1
]}

机构：

[1] DEPT CHEM SCI & TECHNOL,I-33100 UDINE,ITALY

来源：

FEBS LETTERS | 1993年 / 330卷 / 02期

关键词：

VITAMIN-E; ALPHA-TOCOPHEROL; COPPER; PHOSPHOLIPID HYDROPEROXIDE; LOW DENSITY LIPOPROTEIN; ATHEROSCLEROSIS;

D O I：

10.1016/0014-5793(93)80267-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When exposed to Cu2+, alpha-tocopherol, in detergent dispersion, is rapidly oxidised. Moreover, if phospholipids and traces of their hydroperoxide derivatives are included in these dispersions, Cu2+ initiates lipid peroxidation, the rate of which is dramatically stimulated by alpha-tocopherol. The observation that the rate of alpha-tocopherol consumption is identical in the absence and in the presence of lipids undergoing peroxidation, apparently rules out any antioxidant effect, These results are consistent with a prooxidant effect of vitamin E, mediated by its capability to reduce Cu2+ to Cu+ which, in tum, produces, from lipid hydroperoxides, the highly reactive alkoxyl radicals. Present data highlight the risk of misleading results in interpreting the significance of lags in peroxidation of LDL challenged with Cu2+.

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页码：174 / 176

页数：3

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