CUCURBITACINS - DIFFERENTIAL CYTOTOXICITY, DEREPLICATION AND FIRST ISOLATION FROM GONYSTYLUS-KEITHII

被引：38

作者：

FULLER, RW ^{[1
]}

CARDELLINA, JH ^{[1
]}

CRAGG, GM ^{[1
]}

BOYD, MR ^{[1
]}

机构：

[1] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,DRUG DISCOVERY RES & DEV LAB,FREDERICK,MD 21702

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 10期

关键词：

D O I：

10.1021/np50112a015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A characteristic pattern of differential cytotoxicity of extracts of Iberis amara seeds, predominantly toward renal tumor, brain rumor, and melanoma cell lines in the NCI human disease-oriented tumor screening panel, was traced to cucurbitacins E [1] and I [2]. This same differential cytotoxicity profile was detected in extracts of Begonia plebeja and Gonystylus keithii. Computer-assisted recognition of these profiles was followed by a rapid chemical fractionation, thus permitting the efficient dereplication of chose extracts containing cucurbitacins B [3] and D [4], respectively. This is the first report of cucurbitacins from the genus Gonystylus.

引用

页码：1442 / 1445

页数：4

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