THE EFFECTS OF EPILEPTIC CORTICAL ACTIVITY ON THE DEVELOPMENT OF CALLOSAL PROJECTIONS

被引:45
作者
GRIGONIS, AM
MURPHY, EH
机构
[1] MED COLL PENN,EPPI,DEPT ANAT & NEUROBIOL,PHILADELPHIA,PA 19129
[2] HAHNEMANN UNIV,DEPT ANAT,PHILADELPHIA,PA 19102
来源
DEVELOPMENTAL BRAIN RESEARCH | 1994年 / 77卷 / 02期
关键词
EPILEPSY; CORPUS CALLOSUM; DEVELOPMENT; NEURAL ACTIVITY;
D O I
10.1016/0165-3806(94)90200-3
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The effect of epileptic neural activity on the postnatal development of the corpus callosum was studied. Epileptiform activity was induced in the visual cortex of postnatal rabbits by continuous infusion of penicillin. Callosal projections of the occipital cortex were studied in rabbits aged at least 4 weeks. In these penicillin-exposed rabbits, the visual callosal projections extended through most of area 17 in a projection pattern characteristic of neonatal rabbits, rather than being restricted to a narrow callosal zone at the lateral border of area 17, as they usually are by this age. The results indicate that epileptic cortical activity stabilizes immature callosal projections which are normally eliminated during development. The maintenance of such immature and non-specific projections in the mature CNS may interfere with normal cortical functions and could underlie the cognitive deficits which have been observed following childhood epilepsy.
引用
收藏
页码:251 / 255
页数:5
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