2 NEW BIOACTIVE CYCLIC PEROXIDES FROM THE MARINE SPONGE PLAKORTIS-ANGULOSPICULATUS

Two new antifungal and cytotoxic cyclic-peroxide-containing acids, 1 and 3, were isolated from a marine sponge, Plakortis angulospiculatus, which was collected by scuba off the coast of Venezuela. The structures were elucidated through spectral and chemical analysis of the corresponding methyl esters, 2 and 4. The acids are potent cytoxic and antifungal agents although their esters are only cytotoxic. © 1990, American Chemical Society. All rights reserved.