OXYTOCIN CONTRACTS RAT UTERINE SMOOTH-MUSCLE IN CA2+-FREE MEDIUM WITHOUT ANY PHOSPHORYLATION OF MYOSIN LIGHT CHAIN

被引：43

作者：

OISHI, K

TAKANOOHMURO, H

MINAKAWAMATSUO, N

SUGA, O

KARIBE, H

KOHAMA, K

UCHIDA, MK

机构：

[1] TOKYO METROPOLITAN INST MED SCI,BUNKYO KU,TOKYO 113,JAPAN

[2] GUNMA UNIV,DEPT PHARMACOL,MAEBASHI,GUNMA 371,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)90898-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Contraction of rat uterine smooth muscle related to phosphorylation state of myosin light chain under various conditions was investigated. In the Ca2+-containing medium, both high K+ and oxytocin induced marked contraction of the muscle accompanied by pronounced phosphorylation of myosin light chain. In the Ca2+-free medium, although both vanadate and oxytocin induced slight contraction, phosphorylation of myosin light chain was only evident for vanadate but not for oxytocin. It was suggested that another mechanism distinct from myosin light chain phosphorylation might be involved in Ca2+-independent contraction of uterine smooth muscle elicted by oxytocin. © 1991.

引用

页码：122 / 128

页数：7

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