GENETIC-POLYMORPHISM OF THE MURINE MYOGENIC GENE MYO-D1

被引：4

作者：

KAY, PH ^{[1
]}

JACOBSEN, PF ^{[1
]}

ZHENG, MH ^{[1
]}

PAPADIMITRIOU, JM ^{[1
]}

机构：

[1] ROYAL PERTH HOSP,DEPT NEUROPATHOL,PERTH,WA 6000,AUSTRALIA

来源：

GENE | 1991年 / 99卷 / 02期

基金：

英国医学研究理事会;

关键词：

CHROMOSOMAL DNA; MOUSE STRAINS; RECOMBINANT DNA; F1; F2; HYBRIDS; RESTRICTION ENDONUCLEASES; SOUTHERN BLOTTING; LINKAGE DISEQUILIBRIUM; PHOSPHOPROTEIN;

D O I：

10.1016/0378-1119(91)90138-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Polymorphism of the myogenic gene, Myo-D1, has been sought to examine genetic mechanisms which control skeletal muscle development. By Southern analysis, three restriction-fragment length polymorphisms (RFLPs) have been found in various mouse strains using the TaqI, SacI and BglII restriction endonucleases and a full-length cDNA Myo-D1 probe. Reference to the distribution of RFLPs in different mouse strains derived from Mus mus (M.m.) domesticus and M.m. musculus subspecies suggests that Myo-D1 rearrangements are subject to nonrandom association. The biological significance of RFLP of the Myo-D1 gene is yet to be determined.

引用

页码：273 / 277

页数：5

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