ASCORBATE REQUIREMENT FOR HYDROXYLATION AND SECRETION OF PROCOLLAGEN - RELATIONSHIP TO INHIBITION OF COLLAGEN-SYNTHESIS IN SCURVY

被引:261
作者
PETERKOFSKY, B
机构
关键词
COLLAGEN; PROTEOGLYCAN; SCURVY; ASCORBATE; INSULIN-LIKE GROWTH FACTORS;
D O I
10.1093/ajcn/54.6.1135s
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Vitamin C deficiency is associated with defective connective tissue, particularly in wound healing. Ascorbate is required for hydroxylation of proline residues in procollagen and hydroxyproline stabilizes the collagen triple helical structure. Consequently, ascorbate stimulates procollagen secretion. However, collagen synthesis in ascorbate-deficient guinea pigs is decreased with only moderate effects on proline hydroxylation. Proteoglycan synthesis, which does not require ascorbate, also is decreased and both effects are correlated with the extent of weight loss during scurvy. Fasting, with ascorbate supplementation, produces similar effects. Both functions are inhibited in cells cultured in sera from either scorbutic or starved guinea pigs and inhibition is reversed with insulin-like growth factor (IGF)-I. The inhibitor appears to consist of two IGF-binding proteins induced during vitamin C deficiency and starving and may be responsible for in vivo inhibition of collagen and proteoglycan synthesis.
引用
收藏
页码:S1135 / S1140
页数:6
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