H-1-NMR STUDIES OF THE INTERACTIONS OF 2 DISTAMYCIN ANALOGS WITH THE DODECAMER D(CGCGAATTCGCG)2

被引：7

作者：

CONTE, MR ^{[1
]}

FATTORUSSO, E ^{[1
]}

PALOMA, LG ^{[1
]}

MAYOL, L ^{[1
]}

机构：

[1] UNIV NAPOLI FED 2,DIPARTIMENTO CHIM SOSTANZE NAT,VIA DOMENICO MONTESANO 49,I-80131 NAPLES,ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)80234-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

High resolution proton NMR techniques have been used to study the interaction between the self complementary Dickerson dodecamer d(CGCGAATTCGCG)2 and two distamycin analogues containing a retroinverted amide bond. The results indicated that both analogues, although binding the Dickerson dodecamer less strongly than distamycin, span the central AATT segment in the minor groove in a similar fashion.

引用

页码：1299 / 1304

页数：6

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