MOLECULAR CHAPERONES IN CELLULAR PROTEIN-FOLDING

被引：20

作者：

MARTIN, J ^{[1
]}

HARTL, FU ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,CELLULAR BIOCHEM & BIOPHYS PROGRAM,NEW YORK,NY 10021

来源：

BIOESSAYS | 1994年 / 16卷 / 09期

关键词：

D O I：

10.1002/bies.950160916

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of 'molecular chaperones' has dramatically changed our concept of cellular protein folding. Rather than folding spontaneously, most newly synthesized polypeptide chains seem to acquire their native conformation in a reaction mediated by these versatile helper proteins. Understanding the structure and function of molecular chaperones is likely to yield useful applications for medicine and biotechnology in the future.

引用

页码：689 / 692

页数：4

共 43 条

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