RETINOBLASTOMA, CHROMOSOME-13, AND INVITRO CELLULAR RADIOSENSITIVITY

被引：32

作者：

NOVE, J ^{[1
]}

LITTLE, JB ^{[1
]}

WEICHSELBAUM, RR ^{[1
]}

NICHOLS, WW ^{[1
]}

HOFFMAN, E ^{[1
]}

机构：

[1] INST MED RES, DEPT CYTOGENET, CAMDEN, NJ 08103 USA

来源：

CYTOGENETICS AND CELL GENETICS | 1979年 / 24卷 / 03期

关键词：

D O I：

10.1159/000131374

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Five diploid fibroblast strains from patients with deletions mapping in the long arm of chromosome 13 and three strains bearing partial trisomies of chromosome 13 were assayed for clonogenic survival following X-irradiation. Results of these experiments suggest the existence of a region on 13ql4 which is related to increased sensitivity to cell killing in vitro by X-rays. This locus seems to be distinct from but close to the retinoblastoma locus, which has been associated with the same band. © 1979 S. Karger AG, Basel.

引用

页码：176 / 184

页数：9

共 26 条

[1]

ABRAMSON DH, 1976, T AM ACAD OPHTHALMOL, V81, pP454

[2] (13) TERMINAL DELETION, 46 CHROMOSOMES - REPOSITORY IDENTIFICATION NO GM-250 [J].