INDUCTION OF ALLOGRAFT TOLERANCE TO THE H-Y-ANTIGEN IN ADULT C57BL/6 MICE - DIFFERENTIAL-EFFECTS ON DELAYED-TYPE HYPERSENSITIVITY AND CYTOLYTIC T-LYMPHOCYTE ACTIVITY

被引:11
作者
BUSKER, AE [1 ]
MILLER, SD [1 ]
MELVOLD, RW [1 ]
机构
[1] NORTHWESTERN UNIV, SCH MED, DEPT MICROBIOL IMMUNOL, 303 E CHICAGO AVE, CHICAGO, IL 60611 USA
关键词
D O I
10.1016/0008-8749(90)90076-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
This study describes the induction of allograft tolerance to the "male-specific," minor histocompatibility antigen, H-Y, in adult C57BL/6 female mice, and the effects of this tolerance induction on two immune parameters associated with graft rejection: delayed-type hypersensitivity (DTH) and cytolytic T-lymphocytes (CTL). B6 females tolerized to H-Y, by a single iv injection of C57BL/6 male lymphocytes, exhibited prolonged or permanent survival of B6 male tail skin grafts. Graft-induced DTH against H-Y antigen was reduced or abrogated in tolerized females. Delayed onset of graft rejection in partially tolerant females correlated with delayed onset of DTH, and eventual rejection of grafts was accompanied by an increase in H-Y-specific DTH. In contrast, H-Y-specific CTL activity was not consistent with graft status. These data demonstrate a correlation between H-Y-specific DTH and rejection of male skin grafts by B6 female mice and are most consistent with a major effector role for DTH in chronic graft rejection. © 1990.
引用
收藏
页码:225 / 234
页数:10
相关论文
共 36 条
[1]   GENE GOVERNING FEMALE IMMUNE RESPONSE TO MALE ANTIGEN IN MICE [J].
BAILEY, DW ;
HOSTE, J .
TRANSPLANTATION, 1971, 11 (04) :404-+
[2]  
BAILEY DW, 1960, TRANSPLAN B, V7, P394
[3]  
BIANCHI ATJ, 1986, J IMMUNOL, V137, P433
[4]   A SECOND STUDY ON H-Y TRANSPLANTATION ANTIGEN IN MICE [J].
BILLINGHAM, RE ;
SILVERS, WK ;
WILSON, DB .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1965, 163 (990) :61-+
[5]  
BRENT L, 1958, LANCET, V2, P561
[6]  
CERROTTINI JC, 1974, ADV IMMUNOL, V18, pG7
[7]   MONOCLONAL-ANTIBODIES TO PROMOTE MARROW ENGRAFTMENT AND TISSUE GRAFT TOLERANCE [J].
COBBOLD, SP ;
MARTIN, G ;
QIN, S ;
WALDMANN, H .
NATURE, 1986, 323 (6084) :164-166
[8]   EFFECT OF INVIVO EXPOSURE TO ALLOGENEIC CELLS UPON SUBSEQUENT INVITRO T-CELL RESPONSES AND UPON ALLOGRAFT-REJECTION [J].
COOLEY, MA .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1978, 7 (05) :371-380
[9]   ABROGATION OF THE IMMUNOSUPPRESSIVE EFFECT OF DONOR SPLEEN-CELLS ON RENAL-ALLOGRAFTS IN THE RAT BY IRRADIATION OR HEAT-TREATMENT [J].
CRANSTON, D ;
WOOD, KJ ;
MORRIS, PJ .
TRANSPLANTATION, 1986, 42 (03) :302-306
[10]   THE ROLES OF HOST AND DONOR CELLS IN THE REJECTION OF SKIN ALLOGRAFTS BY T-CELL-DEPRIVED RATS INJECTED WITH SYNGENEIC T-CELLS [J].
DALLMAN, MJ ;
MASON, DW ;
WEBB, M .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1982, 12 (06) :511-518