THEORETICAL EVALUATION OF THE 2-DIMENSIONAL TRANSFERRED NUCLEAR OVERHAUSER EFFECT

被引：113

作者：

CAMPBELL, AP

SYKES, BD

机构：

[1] MRC Group in Protein Structure and Function, Department of Biochemistry, University of Alberta, Edmonton

来源：

JOURNAL OF MAGNETIC RESONANCE | 1991年 / 93卷 / 01期

关键词：

D O I：

10.1016/0022-2364(91)90033-P

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A theoretical evaluation of the two-dimensional intramolecular transferred nuclear Overhauser effect (TRNOE) is presented using a full relaxation matrix approach. The application of this analysis to the study of 6-24 residue peptides binding to proteins ranging in size from 18,000 to 80,000 Da is considered. The effects of variables such as mixing time, fraction of bound peptide, free and bound correlation times, and other contributions to spin-lattice relaxation rates are examined in an attempt to offer practical experimental guidelines for the design of a TRNOE experiment. © 1991.

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页码：77 / 92

页数：16

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