SEROTONIN NEURONS PROJECT TO SMALL BLOOD-VESSELS IN THE BRAIN

被引：198

作者：

REINHARD, JF ^{[1
]}

LIEBMANN, JE ^{[1
]}

SCHLOSBERG, AJ ^{[1
]}

MOSKOWITZ, MA ^{[1
]}

机构：

[1] HARVARD UNIV, PETER BENT BRIGHAM HOSP, SCH MED, DEPT MED, BOSTON, MA 02115 USA

来源：

SCIENCE | 1979年 / 206卷 / 4414期

关键词：

D O I：

10.1126/science.482930

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Electrolytic lesions of the nucleus raphe dorsalis and medianus reduce the concentration of serotonin (5-hydroxytryptamine) within rat brain intra-parenchymal blood vessels. The concentration of serotonin within these vessels increases or decreases after the administration of drugs that modify the biosynthesis and degradation of serotonin or destroy nerve terminals by an uptake-dependent mechanism. These studies provide evidence for the existence of a serotonin-containing pathway seemingly analogous to the neuronal projection that terminates on small parenchymal blood vessels from noradrenergic neurons of the locus coeruleus. Copyright © 1979 AAAS.

引用

页码：85 / 87

页数：3

共 59 条

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