RAPID AND INEXPENSIVE TECHNIQUE FOR ASSESSING THE REINFORCING EFFECTS OF OPIATE DRUGS

被引：89

作者：

KATZ, RJ

GORMEZANO, G

机构：

[1] Mental Health Research Institute, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 11卷 / 02期

关键词：

Classical conditioning; D-Ala[!sup]2[!/sup] Leu-Enkephalinamide; Morphine; Opiate; Reinforcement;

D O I：

10.1016/0091-3057(79)90019-4

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Adult male Sprague-Dawley rats were placed in an apparatus consisting of 2 distinctive interconnected chambers. Choice preferences developed and stabilized over three 30 min exposures. Central injection of morphine or an enkephalin analogue in conjunction with placement upon the nonpreferred side caused a preference shift which was not evident in control subjects. Classical conditioning of opiate effects to distinctive environments may offer a novel means of assessing the hedonic effects of these compounds. © 1979.

引用

页码：231 / 233

页数：3

共 13 条

[1]

ADAMS WJ, 1972, P SOC EXP BIOL MED, V140, P770

[2] MORPHINE ADDICTION IN RATS [J].