MOLECULAR EXPRESSION OF THE NEGATIVE GROWTH-FACTOR MURINE BETA-GALACTOSIDE BINDING-PROTEIN (MGBP)

被引：23

作者：

WELLS, V ^{[1
]}

MALLUCCI, L ^{[1
]}

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMASS HOSP,SCH MED,DIV MICROBIOL,CELLULAR & MOLEC BIOL LAB,LONDON SE1 9RT,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1121卷 / 03期

关键词：

BETA-GALACTOSIDE BINDING PROTEIN; NEGATIVE GROWTH FACTOR; CYTOKINE; GLYCAN ASSOCIATION; OLIGOMERIC STATE;

D O I：

10.1016/0167-4838(92)90152-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Characterisation of the negative growth factor mGBP at molecular and biological levels indicates that the protein has no lectin nature and suggests instead a participation in the cytokine network. The protein is shown to be expressed as a monomer in two forms, one of which is non-covalently linked to a glycan complex. This confers greater efficiency to the inhibitor and may favour a paracrine role. The two monomeric forms may oxidise into tetramers which retain biological activity, but lack ability to link to specific saccharide residues.

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页码：239 / 244

页数：6

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