HERPES-SIMPLEX VIRUS TYPE-1 DNA IS PRESENT IN SPECIFIC REGIONS OF BRAIN FROM AGED PEOPLE WITH AND WITHOUT SENILE DEMENTIA OF THE ALZHEIMER TYPE

被引：127

作者：

JAMIESON, GA

MAITLAND, NJ

WILCOCK, GK

YATES, CM

ITZHAKI, RF

机构：

[1] UNIV MANCHESTER,INST SCI & TECHNOL,DEPT OPTOMETRY & VIS SCI,MOLEC NEUROBIOL LAB,POB 88,MANCHESTER M60 1QD,LANCS,ENGLAND

[2] UNIV YORK,DEPT BIOL,YORK YO1 5DD,N YORKSHIRE,ENGLAND

[3] FRENCHAY HOSP,DEPT CARE ELDERLY,BRISTOL BS16 1LE,AVON,ENGLAND

[4] UNIV EDINBURGH,DEPT PHARMACOL,MRC,BRAIN METAB UNIT,EDINBURGH EH8 9YL,MIDLOTHIAN,SCOTLAND

来源：

JOURNAL OF PATHOLOGY | 1992年 / 167卷 / 04期

关键词：

HERPES-SIMPLEX VIRUS TYPE-1 (HSV1); ALZHEIMERS DISEASE; POLYMERASE CHAIN REACTION; HUMAN BRAIN;

D O I：

10.1002/path.1711670403

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have investigated the possible involvement of viruses, specifically Herpes simplex virus type 1, in senile dementia of the Alzheimer type (SDAT). Using the highly sensitive polymerase chain reaction, we have detected the viral thymidine kinase gene in post-mortem brain from 14/21 cases of senile dementia of the Alzheimer type and 9/15 elderly normals. The temporal cortex and hippocampus were usually virus-positive; in contrast, the occipital cortex was virus-negative in 9/9 SDAT cases and 5/5 elderly normals. Temporal and frontal cortex from younger normals (five infants and five middle-aged) were negative. Thus, the presence of Herpes simplex virus type 1 DNA is a region-dependent feature of the aged brain.

引用

页码：365 / 368

页数：4

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