SULFATION OF ENDOGENOUS COMPOUNDS AND XENOBIOTICS - INTERACTIONS AND FUNCTION IN HEALTH AND DISEASE

被引：33

作者：

COUGHTRIE, MWH

BAMFORTH, KJ

SHARP, S

JONES, AL

BORTHWICK, EB

BARKER, EV

ROBERTS, RC

HUME, R

BURCHELL, A

机构：

[1] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT MED,DUNDEE DD1 9SY,SCOTLAND

[2] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT CHILD HLTH,DUNDEE DD1 9SY,SCOTLAND

[3] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT OBSTET & GYNAECOL,DUNDEE DD1 9SY,SCOTLAND

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1994年 / 92卷 / 1-3期

基金：

英国惠康基金;

关键词：

SULFATION; SULFOTRANSFERASE; BREAST CANCER; ADVERSE DRUG REACTIONS;

D O I：

10.1016/0009-2797(94)90067-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sulfation is a major detoxication mechanism for endogenous compounds and xenobiotics performed by a family of sulfotransferase isoenzymes. Understanding the normal cellular functions of these different sulfotransferases and the way in which endogenous and exogenous factors are able to influence their activity and expression will provide us with the information necessary to develop novel therapeutic strategies for conditions where sulfation may be implicated. This concept is discussed and is illustrated by examples including adverse drug reactions, fetal development and cancer.

引用

页码：247 / 256

页数：10

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