DETERMINATION OF DEGREE OF CRYSTALLINITY IN SOLID-SOLID EQUILIBRIA

被引：63

作者：

ALLEN, DJ

KWAN, KC

机构：

[1] Merck Sharp and Dohme Research Laboratories, Pennsylvania

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 10期

关键词：

Crystallinity–solid‐solid equilibria; Dissolution rates–surface area relationship; Indomethacin‐PEG systems–dissolution rates; Polymorphic forms–indomethacin; sulfathiazole; Sulfathiazole‐urea systems–dissolution rates;

D O I：

10.1002/jps.2600581004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A method based on dissolution rates was developed for estimating the ratio of crystalline drug to that dispersed at the molecular level within a carrier. In two diverse systems, it was shown that under appropriately chosen conditions, the dissolution rate of the drug was linearly related to its degree of crystallinity. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1190 / &

共 11 条

[1]

FINDLAY A, 1951, PHASE RULE, P471

[2]

FINDLAY A, 1951, PHASE RULE, P170

[3]

FINDLAY A, 1951, PHASE RULE, P176

[4]

FINDLAY A, 1951, PHASE RULE, P476

[5] INCREASING DISSOLUTION RATES AND GASTROINTESTINAL ABSORPTION OF DRUGS VIA SOLID SOLUTIONS AND EUTECTIC MIXTURES I - THEORETICAL CONSIDERATIONS AND DISCUSSION OF LITERATURE [J].