DIURETICS . 4-SUBSTITUTED 3-SULFAMOYLBENZOIC ACID HYDRAZIDES

被引：8

作者：

HOEFLE, ML

BLOUIN, LT

DEWALD, HA

HOLMES, A

WILLIAMS, D

机构：

[1] Research Laboratories, Davis and Company, Ann Arbor, Michigan 48106, Parke

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 05期

关键词：

D O I：

10.1021/jm00311a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-substituted 3-sulfamoylbenzoic acid hydrazides was prepared and examined for diuretic activity. Chlorine was the preferred substituent in the 4 position, and the 2,2-dialkylhydrazides were found to be the most potent diuretic agents in this class. The corresponding benzohydmxamic acid and methyl ester was found to be equipotent with 4-chloro-3-sulfamoylbenzoic acid hydrazide. © 1968, American Chemical Society. All rights reserved.

引用

页码：970 / &

共 6 条

[1]

DEWALD HA, 1962, Patent No. 3043874

[2]

KAUMP D. H., 1964, J NEW DRUGS, V4, P21

[3] ALKALINE-EARTH BOROHYDRIDES AND THEIR APPLICATIONS IN ORGANIC SYNTHESES [J].