SCHIZOPHRENIA AFTER PRENATAL EXPOSURE TO 1957 A2-INFLUENZA EPIDEMIC

被引：326

作者：

OCALLAGHAN, E

SHAM, P

TAKEI, N

GLOVER, G

MURRAY, RM

机构：

[1] INST PSYCHIAT,DEPT PSYCHOL MED,DE CRESPIGNY PK,LONDON SE5 8AF,ENGLAND

[2] WESTMINSTER MED SCH & HOSP,DEPT COMMUNITY MED,LONDON SW1P 2AP,ENGLAND

[3] UNIV LONDON KINGS COLL HOSP,LONDON SE5 8RX,ENGLAND

来源：

LANCET | 1991年 / 337卷 / 8752期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0140-6736(91)92919-S

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The birth dates of schizophrenic inpatients in eight health regions in England and Wales were reviewed for any effect of the 1957 A2 influenza epidemic. 5 months after the peak infection prevalence, the number of births of individuals who later developed schizophrenia was 88% higher than the average number of such births in the corresponding periods of the 2 previous and the next 2 years. This finding is in accordance with a study from Helsinki and with clinical and neuropathological evidence of aberrant fetal brain development in the pathogenesis of schizophrenia.

引用

页码：1248 / 1250

页数：3

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