AGE-RELATED LOSS OF AUDITORY-SENSITIVITY IN 2 MOUSE GENOTYPES

被引:179
作者
LI, HS
BORG, E
机构
[1] KAROLINSKA HOSP,DEPT AUDIOL,S-10401 STOCKHOLM 60,SWEDEN
[2] KAROLINSKA INST,DEPT PHYSIOL 2,S-10401 STOCKHOLM 60,SWEDEN
关键词
PRESBYCUSIS; AGING PROCESS; MOUSE GENOTYPE; ABR THRESHOLD; FREQUENCY-SPECIFIC; INDIVIDUAL VARIABILITY;
D O I
10.3109/00016489109138418
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Frequency-specific auditory brainstem responses (ABR) (frequency range 2-31.5 kHz) were used to describe age-dependent alterations in frequency sensitivity in CBA/ca (to 30 months) and C57BL/6J (to 16 months) mouse genotypes. The two strains displayed an age-related loss similar to that of humans, with a primary decline in high-frequency sensitivity. CBA mice showed a slow, yet gradual decrease in sensitivity to high- followed by low-frequency until 18 months of age and a rapid deterioration at all frequencies thereafter. C57 mice demonstrated precocious aging in auditory sensitivity in an unsteady rather than gradual manner. By testing the same individuals on repeated occasions it was shown that, for C57 mice, the degenerative process was more precipitous with three phases, and that the individual variability was larger than that of CBA mice. It is suggested that the two mouse genotypes can be used to express the different aspects of human presbycusis in individual variability and modes of gradual or staggered progression.
引用
收藏
页码:827 / 834
页数:8
相关论文
共 19 条
[1]   AGE-RELATED HAIR CELL LOSS IN SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE RATS [J].
BORG, E ;
VIBERG, A .
HEARING RESEARCH, 1987, 30 (2-3) :111-118
[2]   HAIR CELL LOSS AS A FUNCTION OF AGE IN NORMAL COCHLEA OF GUINEA-PIG [J].
COLEMAN, JW .
ACTA OTO-LARYNGOLOGICA, 1976, 82 (1-2) :33-40
[3]   PRESBYCUSIS [J].
GATES, GA ;
CASPARY, DM ;
CLARK, W ;
PILLSBURY, HC ;
BROWN, SC ;
DOBIE, RA .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1989, 100 (04) :266-271
[4]   PHYSIOLOGICAL ASSAYS FOR BIOLOGICAL AGE IN MICE - RELATIONSHIP OF COLLAGEN, RENAL-FUNCTION, AND LONGEVITY [J].
HARRISON, DE ;
ARCHER, JR .
EXPERIMENTAL AGING RESEARCH, 1983, 9 (04) :245-251
[5]  
HENRY KR, 1981, ARCH OTOLARYNGOL, V107, P92
[6]  
HENRY KR, 1980, AUDIOLOGY, V19, P369
[7]   AGE-RELATED AUDITORY LOSS IN THE MONGOLIAN GERBIL [J].
HENRY, KR ;
MCGINN, MD ;
CHOLE, RA .
ARCHIVES OF OTO-RHINO-LARYNGOLOGY-ARCHIV FUR OHREN-NASEN-UND KEHLKOPFHEILKUNDE, 1980, 228 (04) :233-238
[8]  
Henry KR, 1983, AUDITORY PSYCHOBIOLO, P470
[9]   THE INFLUENCE OF PRENATAL GAMMA-IRRADIATION ON THE AGING OF THE COCHLEA [J].
HULTCRANTZ, M ;
ANNIKO, M ;
BORG, E .
ACTA OTO-LARYNGOLOGICA, 1989, 108 (5-6) :414-423
[10]   AGING AND THE AUDITORY BRAIN-STEM RESPONSE IN MICE WITH SEVERE OR MINIMAL PRESBYCUSIS [J].
HUNTER, KP ;
WILLOTT, JF .
HEARING RESEARCH, 1987, 30 (2-3) :207-218