CO-SEGREGATION OF A GENE ENCODING A DELETION LIGAND FOR TCRB-V3+ T-CELLS WITH MTV-3

被引：45

作者：

FAIRCHILD, S ^{[1
]}

KNIGHT, AM ^{[1
]}

DYSON, PJ ^{[1
]}

TOMONARI, K ^{[1
]}

机构：

[1] MRC,CLIN RES CTR,TRANSPLANTAT BIOL SECT,WATFORD RD,HARROW HA1 3UJ,MIDDX,ENGLAND

来源：

IMMUNOGENETICS | 1991年 / 34卷 / 04期

关键词：

D O I：

10.1007/BF00215257

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A gene encoding the endogenous superantigen Mls(c), which deletes Tcrb-V3+ T cells in the NOD inbred mouse strain, was found to co-segregate with Mtv3 on chromosome 11. This identifies a fourth gene encoding a deletion ligand for Tcrb-V3+ T cells and extends recently published observations in support of the hypothesis that a number of endogenous superantigens are the products of Mtv proviruses.

引用

页码：227 / 230

页数：4

共 30 条

[1] PREFERENTIAL EXPRESSION OF THE T-CELL RECEPTOR V-BETA-3 GENE BY MLSC REACTIVE T-CELLS [J].

ABE, R ;

VACCHIO, MS ;

FOX, B ;

HODES, RJ .

NATURE, 1988, 335 (6193) :827-830

[2] THE MHC MOLECULE I-E IS NECESSARY BUT NOT SUFFICIENT FOR THE CLONAL DELETION OF V-BETA-11-BEARING T-CELLS [J].

BILL, J ;

KANAGAWA, O ;

WOODLAND, DL ;

PALMER, E .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (04) :1405-1419

[3] V-BETA-17 GENE POLYMORPHISM IN WILD-DERIVED MOUSE STRAINS - 2 AMINO-ACID SUBSTITUTIONS IN THE V-BETA-17 REGION GREATLY ALTER T-CELL RECEPTOR SPECIFICITY [J].

CAZENAVE, PA ;

MARCHE, PN ;

JOUVINMARCHE, E ;

VOEGTLE, D ;

BONHOMME, F ;

BANDEIRA, A ;

COUTINHO, A .

CELL, 1990, 63 (04) :717-728

[4] GENES ENCODING LIGANDS FOR DELETION OF V-BETA-11 T-CELLS COSEGREGATE WITH MAMMARY-TUMOR VIRUS GENOMES [J].

DYSON, PJ ;

KNIGHT, AM ;

FAIRCHILD, S ;

SIMPSON, E ;

TOMONARI, K .

NATURE, 1991, 349 (6309) :531-532

[5]

FESTENSTEIN H, 1973, TRANSPLANT REV-DENMA, V15, P62

[6] LINKAGE OF MLS GENES TO ENDOGENOUS MAMMARY-TUMOR VIRUSES OF INBRED MICE [J].

FRANKEL, WN ;

RUDY, C ;

COFFIN, JM ;

HUBER, BT .

NATURE, 1991, 349 (6309) :526-528

[7] A 3RD T-CELL RECEPTOR BETA-CHAIN VARIABLE REGION GENE ENCODES REACTIVITY TO MLS-1A GENE-PRODUCTS [J].

HAPP, MP ;

WOODLAND, DL ;

PALMER, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) :6293-6296

[8] T-CELL TOLERANCE BY CLONAL ELIMINATION IN THE THYMUS [J].

KAPPLER, JW ;

ROEHM, N ;

MARRACK, P .

CELL, 1987, 49 (02) :273-280

[9] A T-CELL RECEPTOR VBETA-SEGMENT THAT IMPARTS REACTIVITY TO A CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX PRODUCT [J].

KAPPLER, JW ;

WADE, T ;

WHITE, J ;

KUSHNIR, E ;

BLACKMAN, M ;

BILL, J ;

ROEHM, N ;

MARRACK, P .

CELL, 1987, 49 (02) :263-271

[10] SELF-TOLERANCE ELIMINATES T-CELLS SPECIFIC FOR MLS-MODIFIED PRODUCTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX [J].

KAPPLER, JW ;

STAERZ, U ;

WHITE, J ;

MARRACK, PC .

NATURE, 1988, 332 (6159) :35-40

← 1 2 3 →