ADDUCTS TO MACROMOLECULES IN THE BIOLOGICAL MONITORING OF WORKERS EXPOSED TO POLYCYCLIC AROMATIC-HYDROCARBONS

被引：43

作者：

DELLOMO, M ^{[1
]}

LAUWERYS, RR ^{[1
]}

机构：

[1] UNIV CATHOLIQUE LOUVAIN,IND TOXICOL & OCCUPAT MED UNIT,CLOS CHAPELLE AUX CHAMPS 3054,B-1200 BRUSSELS,BELGIUM

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 1993年 / 23卷 / 02期

关键词：

POLYCYCLIC AROMATIC HYDROCARBONS; BENZO[A]PYRENE; DNA ADDUCTS; BLOOD PROTEIN ADDUCTS; HUMAN BIOMONITORING; OCCUPATIONAL EXPOSURE;

D O I：

10.3109/10408449309117113

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants. Human exposure occurs through diet, smoking, and polluted air. In some groups of workers exposed to PAHs, epidemiological studies have revealed an increased mortality risk for neoplasms. This paper reviews the principal methods that have been developed recently for the detection of PAH adducts to white blood cell DNA and blood proteins (hemoglobin, albumin) and summarizes observations made on occupationally exposed subjects.

引用

页码：111 / 126

页数：16

共 88 条

[1]

Air quality guidelines for Europe, 1987, WHO REGIONAL PUBLICA, V23

[2] BENZO[A]PYRENE GLOBIN ADDUCTS DETECTED BY SYNCHRONOUS FLUORESCENCE SPECTROPHOTOMETRY - METHOD DEVELOPMENT AND RELATION TO LUNG DNA ADDUCTS IN MICE [J].