CORRELATION BETWEEN TUBULOINTERSTITIAL NEPHROPATHY AND GLOMERULAR-LESIONS INDUCED BY ADRIAMYCIN

被引：6

作者：

GUEZMES, A ^{[1
]}

FERNANDEZ, F ^{[1
]}

GARIJO, F ^{[1
]}

VALBERNAL, F ^{[1
]}

机构：

[1] UNIV CATABRIA,NATL HOSP MARQUES DE VALDECILLA,FAC MED,DEPT PATHOL,AVE VALDECILLA S-N,E-39008 SANTANDER,SPAIN

来源：

NEPHRON | 1992年 / 62卷 / 02期

关键词：

ADRIAMYCIN NEPHROTOXICITY; FOCAL AND SEGMENTAL; GLOMERULOSCLEROSIS; TUBULOINTERSTITIAL NEPHROPATHY; MORPHOMETRY;

D O I：

10.1159/000187033

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

This paper describes a morphometric study of the evolution of tubulointerstitial nephropathy in adriamycin-induced focal and segmental glomerulosclerosis in Wistar rats over 32 weeks old. The earliest changes were located in the glomeruli. In the 10 week of the study, tubulointerstitial nephropathy appeared and, although the interstitial space increased after the 2nd week, this increase only became statistically significant after the 10 week. Proteinuria showed the highest correlation with the interstitial space, however, the interstitial space showed the highest correlation indices with the total number of glomeruli affected and to a lesser extent with adhesions to and thickening of Bowman's capsule.

引用

页码：198 / 202

页数：5

共 15 条

[1]

BENNETT WM, 1982, LAB INVEST, V47, P330

[2]

BERTANI T, 1983, KIDNEY INT, V23, P192

[3]

TUBULOINTERSTITIAL LESIONS MEDIATE RENAL DAMAGE IN ADRIAMYCIN GLOMERULOPATHY [J].