SOLUBLE INTERLEUKIN-2 RECEPTOR, CD4 AND CD8 LEVELS IN MELANOMA - A LONGITUDINAL-STUDY

被引：16

作者：

FIERRO, MT ^{[1
]}

LISA, F ^{[1
]}

NOVELLI, M ^{[1
]}

BERTERO, M ^{[1
]}

BERNENGO, MG ^{[1
]}

机构：

[1] UNIV TURIN,DERMATOL CLIN 1,VIA CHERASCO 23,I-10126 TURIN,ITALY

来源：

DERMATOLOGY | 1992年 / 184卷 / 03期

关键词：

MELANOMA FOLLOW-UP; SOLUBLE INTERLEUKIN-2 RECEPTOR; SOLUBLE CD4; SOLUBLE CD8;

D O I：

10.1159/000247537

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Serum levels of soluble (s) interleukin-2 receptor (IL-2R), sCD4 and sCD8 were analysed in 227 melanoma patients, using a sandwich enzyme immunoassay. Different stages of the disease were considered, and a longitudinal study with a 2-year follow-up was performed. Mean values of sIL-2R were significantly higher than in normal controls in all stages and correlated with the disease progression. sCD8 increases with stage progression were less striking, while sCD4 values were always in the normal range. We conclude that sIL-2R measurement is a useful clinical parameter in monitoring disease evolution in melanoma.

引用

页码：182 / 189

页数：8

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