INHIBITION OF NITRIC-OXIDE SYNTHASE ENHANCES MORPHINE ANTINOCICEPTION IN THE RAT SPINAL-CORD

被引：78

作者：

PRZEWLOCKI, R

MACHELSKA, H

PRZEWLOCKA, B

机构：

[1] Neuropeptide Research Department, Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków

来源：

LIFE SCIENCES | 1993年 / 53卷 / 01期

关键词：

D O I：

10.1016/0024-3205(93)90615-A

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

N(G)-nitro-L-arginine methyl ester (L-NAME, 400-1500mug) , administered intrathecally (ith.) , elicits a slight but dose-related antinociception in rats, assessed by tail-flick and paw pressure tests. L-NAME (400mug) and morphine (0.5mug) coadministered ith. elicit a profound and long-lasting antinociception, which is abolished by ith. administration of 3-morpholino-sydnonimine (SIN-1, 100mug) . Hemoglobin (266mug) administered ith. also slightly potentiates morphine antinociception. These results suggest that nitric oxide (NO) is involved in spinal nociceptive events, and that the increased production of No following the nociceptive input may diminish the efficiency of opioid antinociception in the spinal cord.

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页码：PL1 / PL5

页数：5

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