SERUM LEVELS OF INTERLEUKIN-1-ALPHA, INTERLEUKIN-1-BETA, INTERLEUKIN-6, AND TUMOR-NECROSIS-FACTOR IN PATIENTS WITH ACUTE VIRAL-HEPATITIS

被引：85

作者：

TORRE, D ^{[1
]}

ZEROLI, C ^{[1
]}

GIOLA, M ^{[1
]}

FERRARIO, G ^{[1
]}

FIORI, GP ^{[1
]}

BONETTA, G ^{[1
]}

TAMBINI, R ^{[1
]}

机构：

[1] E&S MACCHI FDN,VARESE,ITALY

来源：

CLINICAL INFECTIOUS DISEASES | 1994年 / 18卷 / 02期

关键词：

D O I：

10.1093/clinids/18.2.194

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum levels of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in patients with acute viral hepatitis were investigated. Twelve patients suffering from acute viral hepatitis were studied; 8 patients presented with acute hepatitis B, 2 patients with acute hepatitis A, and 2 patients with acute hepatitis C. Serum levels of IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha were significantly increased in all patients with acute viral hepatitis. Decreased serum levels of all cytokines were noted in four patients with acute hepatitis B during the recovery phase of infection. In addition, IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha were undetectable at the end of a follow-up period of 6 months. Our study shows that increased levels of IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha are probably related to hepatitis activity and thus may have some role in hepatocytic injury.

引用

页码：194 / 198

页数：5

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