MALYNGAMIDE-H, AN ICHTHYOTOXIC AMIDE POSSESSING A NEW CARBON SKELETON FROM THE CARIBBEAN CYANOBACTERIUM LYNGBYA-MAJUSCULA

被引：54

作者：

ORJALA, J ^{[1
]}

NAGLE, D ^{[1
]}

GERWICK, WH ^{[1
]}

机构：

[1] OREGON STATE UNIV,COLL PHARM,CORVALLIS,OR 97331

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 05期

关键词：

D O I：

10.1021/np50119a019

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Guided by ichthyotoxic activity against goldfish, a new lipopeptide, malyngamide H [1], and its corresponding free acid, 7-methoxytetradec-4(E)-enoic acid [2], have been isolated from the tropical marine cyanobacterium Lyngbya majuscula. The structure of the new carbon skeleton borne by malyngamide H was elucidated on the basis of spectroscopic analysis, mainly 2D nmr. The absolute stereochemistry of the cyclohexenone moiety of malyngamide H [1] was deduced by a combination of 2D NOESY and exciton chirality circular dichroism spectroscopy.

引用

页码：764 / 768

页数：5

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