SIALOGENIC ACTION OF PEPTIDES IN HEN

1. Substance P, physalaemin and eledoisin cause salivary secretion in the hen. 2. Atropine, phentolamine, propranolol and antazoline did not inhibit the peptide induced salivation. The peptide-induced rise in blood pressure was, however, blocked by large doses of phentolamine. 3. In contrast to the substance P preparation (containing only fraction Fa), Zetler's fraction Fc was devoid of sialogogic and hypertensive action. 4. Bovine parotid gland contains a peptide fraction with activity on smooth muscle but different from substance P. 5. Sustance P and eledoisin can clearly be discriminated by their relative activity on salivation in the chicken and the rat and on the guinea pig ileum. The discrimination between substance P and physalaemin in these tests is much less marked and near the limit of significance. © 1968 Springer-Verlag.