PLASMA PROPRANOLOL CONCENTRATIONS AND THE ERYTHROCYTE SEDIMENTATION-RATE

被引:36
作者
SCHNEIDER, RE [1 ]
BISHOP, H [1 ]
HAWKINS, CF [1 ]
机构
[1] QUEEN ELIZABETH HOSP,QUEEN ELIZEBETH MED CTR,BIRMINGHAM B15 2TH,W MIDLANDS,ENGLAND
关键词
D O I
10.1111/j.1365-2125.1979.tb05907.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. The plasma propranolol concentrations after a single oral dose of 40 mg were measured in 25 patients with rheumatoid arthritis and compared with those of 16 patients with Crohn's disease from a previous study. Thirteen healthy volunteers were used as controls. 2. In both diseases some high and some low values occurred. This scatter did not correlate with any symptoms or biochemical or haematological data other than with the erythrocyte sedimentation rate (ESR). 3. Both sets of patients were therefore separated into two groups depending on whether or not their ESRs were above or below 20 mm/l h. In both diseases the plasma propranolol concentrations of the patients with a raised ESR were significantly higher than the controls as well as those of the low ESR group. 4. In rheumatoid arthritis the plasma propranolol concentrations of the patients with a low ESR did not differ from those of the controls, but in Crohn's disease they remained significantly higher. 5. In one patient with Crohn's disease there was a dramatic rise in propranolol concentrations during an exacerbation (ESR 91 mm/l h) compared with those during a remission (ESR 20 mm/l h). 6. A difference in smoking habits did not seem to have been responsible for the difference in plasma propranolol concentrations. 1979 Blackwell Science Ltd
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页码:43 / 47
页数:5
相关论文
共 11 条
  • [1] BABB J, 1976, LANCET, V1, P1413
  • [2] Borga O, 1977, Br J Clin Pharmacol, V4, p627P
  • [3] CONTRIBUTION OF INDIVIDUAL-DIFFERENCES IN GASTRIC-EMPTYING TO VARIABILITY IN PLASMA PROPRANOLOL CONCENTRATIONS
    CASTLEDEN, CM
    GEORGE, CF
    SHORT, MD
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1978, 5 (02) : 121 - 122
  • [4] PROPRANOLOL ABSORPTION IN CROHNS-DISEASE AND CELIAC-DISEASE
    COOPER, BT
    COOKE, WT
    LUCAS, ML
    BLAIR, JA
    [J]. BRITISH MEDICAL JOURNAL, 1976, 2 (6044) : 1135 - 1135
  • [5] RELATIONSHIP OF ACID MICRO-CLIMATE IN RAT AND HUMAN INTESTINE TO MALABSORPTION
    LUCAS, ML
    BLAIR, JA
    COOPER, BT
    COOKE, WT
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1976, 4 (01) : 154 - 156
  • [6] PLASMA-LEVELS OF PROPRANOLOL IN TREATED PATIENTS WITH CELIAC-DISEASE AND PATIENTS WITH CROHNS-DISEASE
    SCHNEIDER, RE
    BABB, J
    BISHOP, H
    MITCHARD, M
    HOARE, AM
    HAWKINS, CF
    [J]. BRITISH MEDICAL JOURNAL, 1976, 2 (6039) : 794 - 795
  • [7] DISPOSITION OF PROPRANOLOL .1. ELIMINATION DURING ORAL ABSORPTION IN MAN
    SHAND, DG
    RANGNO, RE
    [J]. PHARMACOLOGY, 1972, 7 (03) : 159 - &
  • [8] SHAND DG, 1970, CLIN PHARMACOL THER, V11, P112
  • [9] SHANKER LS, 1958, J PHARMACOL EXP THER, V123, P81
  • [10] INFLUENCE OF SMOKING ON INTER-SUBJECT VARIATION IN PENTAZOCINE ELIMINATION
    VAUGHAN, DP
    BECKETT, AH
    ROBBIE, DS
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1976, 3 (02) : 279 - 283