DEREPLICATION OF PHORBOL BIOACTIVES - LYNGBYA-MAJUSCULA AND CROTON-CUNEATUS

被引：28

作者：

BEUTLER, JA ^{[1
]}

ALVARADO, AB ^{[1
]}

SCHAUFELBERGER, DE ^{[1
]}

ANDREWS, P ^{[1
]}

MCCLOUD, TG ^{[1
]}

机构：

[1] NCI,FCRDC,PROGRAM RESOURCES INC,CHEM SYNTH & ANAL LAB,FREDERICK,MD 21702

来源：

JOURNAL OF NATURAL PRODUCTS | 1990年 / 53卷 / 04期

关键词：

D O I：

10.1021/np50070a014

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Lyngbya majuscula and Croton cuneatus were used as prototypes for the dereplication of phorbol ester receptor binding activity using a combination of hplc-uv and online phorbol dibutyrate (PDBu) receptor binding and batch fractionation over either Si gel or diolbonded Si gel. Debromoaplysiatoxin was responsible for the bioactivity of Lyngbya, whereas a complex of potent phorbol esters was detected in C. cuneatus. © 1990, American Chemical Society. All rights reserved.

引用

页码：867 / 874

页数：8

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