FAT-INDUCED JEJUNAL INHIBITION OF GASTRIC-ACID SECRETION AND RELEASE OF PANCREATIC GLUCAGON, ENTEROGLUCAGON, GASTRIC-INHIBITORY POLYPEPTIDE, AND VASOACTIVE INTESTINAL POLYPEPTIDE IN MAN

被引：47

作者：

CHRISTIANSEN, J

BECH, A

FAHRENKRUG, J

HOLST, JJ

LAURITSEN, K

MOODY, AJ

SCHAFFALITZKYDEMUCKADELL, O

机构：

[1] HVIDOVRE HOSP,DEPT SURG GASTROENTEROL,DK-2650 HVIDOVRE,DENMARK

[2] BISPEBJERG HOSP,DEPT CLIN CHEM,DK-2400 COPENHAGEN,DENMARK

[3] UNIV COPENHAGEN,INST MED PHYSIOL C,NOVO RES LABS,COPENHAGEN,DENMARK

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1979年 / 14卷 / 02期

关键词：

Acid secretion; GIP; glucagon; VIP;

D O I：

10.3109/00365527909179862

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effect of intrajejunal (i.j.) infusion of fat on meal-stimulated gastric acid secretion and release of pancreatic glucagon (PG), enteroglucagon (EG), gastric inhibitory polypeptide (GIP), and vasoactive intestinal polypeptide (VIP) was studied in seven healthy volunteers. I.j. fat markedly inhibited meal-stimulated acid secretion as compared to a control study with i.j. saline infusion. The acid inhibition was accompanied by augmented plasma concentrations of EG, GIP, and VIP but not of PG, suggesting that EG, GIP, and VIP may be among mediators of fat-induced jejunal inhibition of acid secretion. Concentration-time relationship makes it unlikely that the observed inhibition could be ascribed to any single peptide studied. © 1979 Informa UK Ltd.

引用

页码：161 / 166

页数：6

共 32 条

[1]

BIEBERDORF FA, 1974, GASTROENTEROLOGY, V66, P343

[2]

BLOOM SR, 1977, GUT, V18, pA963

[3]

BROOKS AM, 1970, GASTROENTEROLOGY, V59, P114

[4]

CHRISTIANSEN J, 1976, SCAND J GASTROENTERO, V11, P219