CATECHOLAMINE METABOLISM IN PRIMARY ANOREXIA-NERVOSA

被引:146
作者
GROSS, HA [1 ]
LAKE, CR [1 ]
EBERT, MH [1 ]
ZIEGLER, MG [1 ]
KOPIN, IJ [1 ]
机构
[1] NIMH, CLIN SCI LAB, EXPTL THERAPEUT SECT, BETHESDA, MD 20014 USA
关键词
D O I
10.1210/jcem-49-6-805
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Abnormalities in neuroendocrine function and sympathetic nervous system activity appear to be present in primary anorexia nervosa. Hypothalamic catecholamines are involved in control of endocrine function and norepinephrine is released from sympathetic nerve endings. Because of possible abnormalities in catecholamine metabolism, plasma levels of norepinephrine and urinary excretion of homovanillic acid and 3-methoxy-4-hydroxyphenyl glycol were studied in female patients with primary anorexia nervosa before and after significant clinical improvement and compared with normal female volunteers. During the phase of the disease in which body weights were more than 20-25% below ideal, patients' blood pressures and pulse rates, plasma levels of norepinephrine, and 24-h urinary excretion of 3-methoxy-4-hydroxyphenol glycol and homovanillic acid were lower than those of a group of normal volunteers. After weight gain, these parameters increased to nearnormal levels. At no time was plasma dopamine-β-hydroxylase activity abnormal. The results suggest that abnormalities in catecholamine metabolism in primary anorexia nervosa are caused by starvation, and that neuronal functions dependent on aminergic neurotransmission may be altered as a result. © 1979 by The Endocrine Society.
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页码:805 / 809
页数:5
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