CHROMATOGRAPHIC DEVELOPMENTS IN LOW FLOW DELIVERY FOR LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY

被引:9
作者
BALOGH, MP
STACEY, CC
机构
[1] Waters Chromatography Division, Millipore Corporation, Milford, MA 01757
来源
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 562卷 / 1-2期
关键词
D O I
10.1016/0378-4347(91)80566-U
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A method has been demonstrated for producing accurate, reproducible gradients at low microliter per minute flow-rates suitable for liquid chromatographic-mass spectrometric (LC-MS) applications using capillary chromatography columns. The technique employs a low-cost, well characterized balance-column flow-splitter which can be simply added to a high-performance LC-MS solvent delivery system. Performance of the pump for LC-MS techniques at higher flow-rates is preserved.
引用
收藏
页码:73 / 79
页数:7
相关论文
共 8 条
[1]   ONLINE LIQUID-CHROMATOGRAPHY FAST-ATOM BOMBARDMENT OF PROTEIN TRYPTIC DIGESTS [J].
BELL, DJ ;
BRIGHTWELL, MD ;
NEVILLE, WA ;
WEST, A .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1990, 4 (03) :88-91
[2]   MICROBORE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY FOR THE ANALYSIS OF PROTEOLYTIC DIGESTS BY CONTINUOUS-FLOW FAST-ATOM BOMBARDMENT MASS-SPECTROMETRY [J].
CAPRIOLI, RM ;
MOORE, WT ;
DAGUE, B ;
MARTIN, M .
JOURNAL OF CHROMATOGRAPHY, 1988, 443 :355-362
[4]  
NORWOOD DL, 1988, RAPID COMMUN MASS SP, V2, P80
[5]  
NOVOTNY M, 1981, ANAL CHEM, V53, P1294
[6]   GRADIENT ELUTION CHROMATOGRAPHY WITH MICROBORE COLUMNS [J].
SCHWARTZ, HE ;
KARGER, BL ;
KUCERA, P .
ANALYTICAL CHEMISTRY, 1983, 55 (11) :1752-1760
[7]  
SCHWARTZ HE, 1984, AM LAB OCT, P43
[8]   GRADIENT ELUTION SYSTEM FOR CAPILLARY AND MICRO HPLC [J].
VANDERWAL, S ;
YANG, FJ .
JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY & CHROMATOGRAPHY COMMUNICATIONS, 1983, 6 (04) :216-217