NEW CYCLOBUTYL ANALOGS OF ADENOSINE AND GUANOSINE .1. SYNTHESIS OF THE 9-[3,3-BIS(HYDROXYMETHYL)CYCLOBUTYL]PURINE NUCLEOSIDE ANALOGS

被引：13

作者：

BOUMCHITA, H ^{[1
]}

LEGRAVEREND, M ^{[1
]}

HUEL, C ^{[1
]}

BISAGNI, E ^{[1
]}

机构：

[1] CTR UNIV ORSAY,INST CURIE BIOL,INSERM,U219,F-91405 ORSAY,FRANCE

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 06期

关键词：

D O I：

10.1002/jhet.5570270655

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1‐amino‐3,3‐bis(benzyloxymethyl)cyclobutane has been performed from 3,3‐bis(benzyloxymethyl)cyclobutanone, via the corresponding oxime which was reduced with lithium aluminum hydride. The amine thus obtained led to two new cyclobutyl analogs of adenosine and guanosine which were devoid of antiviral activity against HSV‐1, HCMV and HIV in cell culture. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：1815 / 1819

页数：5

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