ABSORPTION OF HUMAN CALCITONIN ACROSS THE RAT COLON INVIVO

被引：39

作者：

HASTEWELL, J ^{[1
]}

LYNCH, S ^{[1
]}

WILLIAMSON, I ^{[1
]}

FOX, R ^{[1
]}

MACKAY, M ^{[1
]}

机构：

[1] CIBA GEIGY PHARMACEUT CORP,DRUG PREFORMULAT & DELIVERY,WIMBLEHURST RD,HORSHAM RH12 4AB,W SUSSEX,ENGLAND

来源：

CLINICAL SCIENCE | 1992年 / 82卷 / 05期

关键词：

ABSORPTION; COLON; HUMAN CALCITONIN; HYPOCALCEMIC RESPONSE; ORAL DRUG DELIVERY;

D O I：

10.1042/cs0820589

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

1. We studied the absorption of human calcitonin across the colon of juvenile female rats in vivo. Both pharmaco-kinetic and pharmacodynamic parameters were monitored to measure absorption. 2. Intracolonically administered human calcitonin at doses of 0.1-5.0 mg/kg resulted in a dose-dependent reduction in plasma calcium levels. 3. The bioavailability of intracolonically administered human calcitonin at doses of 5.0, 1.0 and 0.1 mg/kg was 0.5%, 0.9% and 0.2%, respectively. 4. Immunohistochemistry showed that human calcitonin transport across the rat colon was rapid and that a significant amount was via a transcellular pathway. 5. We conclude that human calcitonin crosses the gastrointestinal tract of rats in significant amounts and that this demonstrates the feasibility of an oral form for clinical use.

引用

页码：589 / 594

页数：6

共 25 条

[1] CALCITONIN THERAPY FOR BONE-DISEASE AND HYPERCALCEMIA [J].