FETAL NUCHAL EDEMA - ASSOCIATED MALFORMATIONS AND CHROMOSOMAL DEFECTS

被引：83

作者：

NICOLAIDES, KH

AZAR, G

SNIJDERS, RJM

GOSDEN, CM

机构：

[1] Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital

[2] Medical Research Council, Human Genetics Unit, Edinburgh

来源：

FETAL DIAGNOSIS AND THERAPY | 1992年 / 7卷 / 02期

关键词：

FETAL NUCHAL EDEMA; PRENATAL DIAGNOSIS; ULTRASONOGRAPHY; FETAL KARYOTYPE; CORDOCENTESIS;

D O I：

10.1159/000263659

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

During an 8-year Period, oedema in the dorsal cervical region that produces a characteristic tremor on ballotement of the fetal head (nuchal oedema) was observed in 145 (7%) of the 2,086 fetuses that underwent karyotyping in our unit because of fetal malformations and/or growth retardation. Nuchal oedema was distinguished from nuchal cystic hygromata and from hydrops foetalis. In 132 (91%) of the cases with nuchal oedema, there were other fetal malformations, and 53 (37%) fetuses had chromosomal abnormalities, mainly trisomy 21 but also other trisomies, deletions or translocations, triploidy and Turner syndrome. Furthermore, the chromosomally normal fetuses with nuchal oedema had a very poor prognosis because, in many cases, there was an underlying skeletal dysplasia, a genetic syndrome or cardiac defect.

引用

页码：123 / 131

页数：9

共 8 条

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