FOOD CONTAINS THE BIOACTIVE PEPTIDE, CYCLO(HIS-PRO)

被引：32

作者：

HILTON, CW

PRASAD, C

VO, P

MOUTON, C

机构：

[1] LOUISIANA STATE UNIV, MED CTR, COMPREHENS MED SECT, NEW ORLEANS, LA 70112 USA

[2] PENNINGTON BIOMED RES CTR, BATON ROUGE, LA 70808 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1992年 / 75卷 / 02期

关键词：

D O I：

10.1210/jc.75.2.375

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cyclo(His-Pro) (CHP) is a cyclic dipeptide with numerous biological activities. As small di- and tripeptides may be absorbed intact when ingested orally, we were interested in examining several common foods for the presence of cyclo(His-Pro)-like immunoreactivity (CHP-LI). In all foods tested, CHP-LI was found at levels 5-1500 times those previously found in human plasma. This CHP-LI was identical to authentic CHP by immunoidentity and chromatographic behavior. We conclude that 1) CHP-LI is readily detectable in several common food sources; 2) this CHP-LI is indistinguishable from authentic CHP; and 3) it is likely the CHP-LI in foods is absorbed in quantities sufficient to cause elevations of CHP-LI in plasma to biologically significant levels.

引用

页码：375 / 378

页数：4

共 23 条

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