EFFECT OF A TOTAL EXTRACT FROM FRAXINUS-ORNUS STEM BARK AND ESCULIN ON ZYMOSAN-INDUCED AND CARRAGEENAN-INDUCED PAW EDEMA IN MICE

被引：32

作者：

STEFANOVA, Z ^{[1
]}

NEYCHEV, H ^{[1
]}

IVANOVSKA, N ^{[1
]}

KOSTOVA, I ^{[1
]}

机构：

[1] BULGARIAN ACAD SCI,CTR PHYTOCHEM,INST ORGAN CHEM,BU-1113 SOFIA,BULGARIA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1995年 / 46卷 / 02期

关键词：

FRAXINUS ORNUS; ESCULIN; COMPLEMENT INHIBITION; ANTIINFLAMMATORY; PAW EDEMA;

D O I：

10.1016/0378-8741(95)01233-4

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This study investigates the total ethanol extract (TE) of the stem bark of Fraxinus ornus and its constituent esculin (EN). They inhibited classical pathway (CP) and alternative pathway (AP) of complement activation in mouse serum. After intraperitoneal administration the total extract displayed antiinflammatory activity in both zymosan- and carrageenan-induced paw oedema in mice. The results suggest that the traditional use of Fraxinus ornus stem bark extracts in the treatment of inflammatory disorders is at least partially due to its coumarin constituents.

引用

页码：101 / 106

页数：6

共 16 条

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