THE FREE-RADICAL SCAVENGER, ALPHA-LIPOIC ACID, PROTECTS AGAINST CEREBRAL ISCHEMIA-REPERFUSION INJURY IN GERBILS

被引：76

作者：

CAO, XH ^{[1
]}

PHILLIS, JW ^{[1
]}

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT PHYSIOL,DETROIT,MI 48202

来源：

FREE RADICAL RESEARCH | 1995年 / 23卷 / 04期

关键词：

ALPHA-LIPOIC ACID; CEREBRAL ISCHEMIA; FREE RADICALS; GERBILS; LIPID PEROXIDATION;

D O I：

10.3109/10715769509065257

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

alpha-lipoic acid (thioctic acid) was tested for its neuroprotective activity in a Mongolian gerbil model of forebrain ischemia/reperfusion. Adult gerbils were treated for 7 days with two intraperitoneal injections per day of alpha-lipoic acid (20 mg/kg), vehicle or saline and on the 7th day the animals were subjected to 5 min of forebrain ischemia. Ischemic injury was assessed by monitoring the increases in locomotor activity and from the extent of damage to the CA1 hippocampal pyramidal cell layer after 5 days of recovery. By both criteria, alpha-lipoic acid was neuroprotective against ischemia/reperfusion evoked cerebral injury.

引用

页码：365 / 370

页数：6

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