PENTOSAN POLYSULFATE SODIUM FOR THERAPY OF INTERSTITIAL CYSTITIS - A DOUBLE-BLIND PLACEBO-CONTROLLED CLINICAL-STUDY

被引:173
作者
MULHOLLAND, SG
HANNO, P
PARSONS, CL
SANT, GR
STASKIN, DR
机构
[1] THOMAS JEFFERSON UNIV, DEPT UROL, PHILADELPHIA, PA 19107 USA
[2] HOSP UNIV PENN, DEPT UROL, PHILADELPHIA, PA 19104 USA
[3] UNIV CALIF SAN DIEGO, MED CTR, DEPT UROL, LA JOLLA, CA 92093 USA
[4] TUFTS UNIV, SCH MED, DEPT UROL, BOSTON, MA 02111 USA
[5] BOSTON UNIV, SCH MED, DEPT UROL, BOSTON, MA 02118 USA
关键词
D O I
10.1016/0090-4295(90)80116-5
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Pentosan polysulfate sodium (PPS) was compared with placebo for the symptomatic therapy of interstitial cystitis in a double-blind, multicenter study. A total of 110 patients were enrolled and treated for three months. In this study, overall improvement of greater than 25 percent was reported by 28 percent of the PPS-treated patients and by 13 percent of the placebo-treated patients (p = 0.03). The investigators' overall evaluation provided similar results, 26 percent vs 11 percent in favor of PPS (p = 0.04). Improvement in pain and pressure to urinate also favored PPS over placebo and approached statistical significance (p = 0.07 and 0.08). The incidence of adverse reactions was 6 percent in the PPS-treated group and 13 percent in the placebo-treated group. All adverse reactions were minor, and treatment was discontinued by I patient in the PPS group and 2 in the placebo group. In this study, PPS was found to be significantly more effective than, and equally as safe as, placebo. © 1990.
引用
收藏
页码:552 / 558
页数:7
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