TIME COURSE OF VENTILATORY DEPRESSION FOLLOWING INDUCTION DOSES OF PROPOFOL AND THIOPENTAL

被引:33
作者
BLOUIN, RT [1 ]
CONARD, PF [1 ]
GROSS, JB [1 ]
机构
[1] UNIV CONNECTICUT, SCH MED, DEPT ANESTHESIOL, FARMINGTON, CT 06032 USA
关键词
ANESTHETICS; INTRAVENOUS; PROPOFOL; THIOPENTAL; CARBON DIOXIDE; VENTILATORY RESPONSE; HYPERCARBIA; LUNGS; VENTILATION; HYPERCAPNIC DRIVE;
D O I
10.1097/00000542-199112000-00003
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
To improve our understanding of the respiratory pharmacology of intravenous induction agents, the authors compared the acute effects of intravenous (iv) propofol 2.5 mg.kg-1 and iv thiopental 4.0 mg.kg-1 on the ventilatory response to CO2 (VER(CO2) of eight healthy volunteers. The Slope of VER(CO2) decreased from 1.75 +/- 0.23 to a minimum of 0.77 +/- 0.14 1 . min-1.mmHg-1 (mean +/- standard error) 90 s after propofol; similarly, the Slope Of VER(CO2) decreased from 1.79 +/- 0.22 to a minimum of 0.78 +/- 0.23 1.min-1.mmHg-1 30 s after thiopental. For both drugs, the slope was less than control in the 0.5-5-min period after injection (P < 0.05). The slope returned to baseline within 6 min after thiopental; in contrast, after propofol, the slope remained less than control for the entire 20-min follow-up period (P < 0.05 at 6-10, 11-15, and 16-20 min after injection). Also, from 6-10, 11-15, and 16-20 min after injection, the slope was less after propofol than at corresponding times after thiopental (P < 0.05). Recovery of consciousness was approximately 4 min slower after propofol than after thiopental; nonetheless, awareness scores returned to baseline within 14 min after both drugs. The authors conclude that propofol 2.5 mg.kg-1 iv produces longer-lasting depression of VER(CO2) than a 4.0 mg.kg-1 iv dose of thiopental; after propofol, ventilatory depression may persist despite apparently complete recovery of consciousness.
引用
收藏
页码:940 / 944
页数:5
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