MOLECULAR MECHANISM OF ETHANOL-METABOLISM BY HUMAN BRAIN TO FATTY-ACID ETHYL-ESTERS

被引：40

作者：

BORA, PS ^{[1
]}

LANGE, LG ^{[1
]}

机构：

[1] WASHINGTON UNIV,JEWISH HOSP ST LOUIS,MED CTR,DEPT MED,ST LOUIS,MO 63110

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1993年 / 17卷 / 01期

关键词：

D O I：

10.1111/j.1530-0277.1993.tb00721.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Ethanol metabolism in the human brain has been documented to occur with the formation of fatty acid ethyl esters. These neutral lipids can disorder membranes and interrupt mitochondrial function. Their formation is under the control of three synthases, localized to grey matter and purified to homogeneity. cDNA cloning demonstrates two of these enzymes to be GSH S-transferases and has enabled initiation of genetic studies of alcohol-induced CNS injury.

引用

页码：28 / 30

页数：3

共 28 条

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