KINETICS OF TRICHLOROETHYLENE ELIMINATION FROM VENOUS-BLOOD AFTER ACUTE INHALATION POISONING

被引:7
作者
KOSTRZEWSKI, P
JAKUBOWSKI, M
KOLACINSKI, Z
机构
[1] Department of Toxic Substances Metabolism, Institute of Occupational Medicine, Lódź
[2] Clinical Toxicology Center, Institute of Occupational Medicine, Lódź
来源
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 1993年 / 31卷 / 02期
关键词
TRICHLOROETHYLENE; POISONING; HUMAN; ACUTE INHALATION EXPOSURE; KINETICS; METABOLIC CLEARANCE RATE; CHROMATOGRAPHY; GAS;
D O I
10.3109/15563659309000403
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
The kinetics of trichloroethylene were examined in three men, 28-36 years old, hospitalized after an acute occupational exposure. The trichloroethylene concentration of venous blood was determined by gas chromatography with headspace analysis; urinary trichloroacetic acid was assayed by the colorimetric method of Fujiwara. The kinetics of blood trichlorethylene (t1/2 21.7 h) and the urinary elimination of trichloracetic acid over six days were used to calculate the total inhalation exposures. Blood trichlorethylene was diagnostically more relevant than urinary trichloracetic acid.
引用
收藏
页码:353 / 363
页数:11
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