NATURAL AUTOANTIBODIES AGAINST THE NERVE GROWTH-FACTOR IN AUTOIMMUNE-DISEASES

被引：40

作者：

DICOU, E ^{[1
]}

HUREZ, D ^{[1
]}

NERRIERE, V ^{[1
]}

机构：

[1] CTR HOSP REG UNIV,IMMUNOL LAB,ANGERS,FRANCE

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1993年 / 47卷 / 02期

关键词：

NERVE GROWTH FACTOR; AUTOANTIBODIES; SERUM; AUTOIMMUNE DISEASES;

D O I：

10.1016/0165-5728(93)90026-U

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

High titers of natural autoantibodies against the nerve growth factor (NGF) were detected in the sera of patients with systemic lupus erythematosus, autoimmune thyroiditis and rheumatoid arthritis. Autoantibodies to NGF from these pathological cases displayed higher avidity for NGF and a higher polyreactivity with certain cytoskeletal proteins and with DNA as compared to those from control human subjects. The biological activity, immunoglobulin composition and physiological relevance of these autoantibodies are discussed.

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页码：159 / 167

页数：9

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