POTENTIAL RADIOPROTECTIVE AGENTS .1. HOMOLOGS OF MELATONIN

被引：44

作者：

BLICKENSTAFF, RT

BRANDSTADTER, SM

REDDY, S

WITT, R

机构：

[1] INDIANA UNIV,SCH MED,DEPT BIOCHEM & MOLEC BIOL,INDIANAPOLIS,IN 46202

[2] INDIANA UNIV,SCH MED,DEPT RADIAT ONCOL,INDIANAPOLIS,IN 46202

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1994年 / 83卷 / 02期

关键词：

D O I：

10.1002/jps.2600830220

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Homologs of melatonin were prepared by acylation of 5-methoxytryptamine with the appropriate acid chloride or anhydride. The products were administered as solutions or suspensions in soybean oil by ip injection to mice 30 min prior to irradiation with 950 cGy of 6 mV photons. Protection was achieved with all compounds, survival rate being maximal for mice treated with the hexanoic amide 5 and the octanoic amide 6.

引用

页码：216 / 218

页数：3

共 15 条

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[2]

BACQ Z M, 1961, Bull Acad R Med Belg, V1, P519

[3]

BAEV I, 1975, ROENTGENOL RADIOL, V14, P50

[4]

BAHN AK, 1972, BASIC MED STATISTICS, P52